710335C

18:1 Cardiolipin

Avanti Research^™ - A Croda Brand

• Synonim(y): tetraoleoyl cardiolipin; 1,1′,2,2′-tetra-(9Z-octadecenoyl) cardiolipin (sodium salt); CL(1′-[18:1(9Z)/18:1(9Z)],3′-[18:1(9Z)/18:1(9Z)])
• Wzór empiryczny (zapis Hilla): C₈₁H₁₄₈O₁₇P₂Na₂
• Numer CAS: 115404-77-8
• Masa cząsteczkowa: 1501.96
• Numer MDL: MFCD00057815
• Kod UNSPSC: 51191904
• NACRES: NA.25

Właściwości

• opis: 1′,3′-bis[1,2-dioleoyl-sn-glycero-3-phospho]-glycerol (sodium salt), chloroform
• Próba: >99% (TLC)
• Formularz: solution
• opakowanie: pkg of 1 × 2.5 mL (710335C-25mg); pkg of 2 × 4 mL (710335C-200mg); pkg of 5 × 4 mL (710335C-500mg)
• producent / nazwa handlowa: Avanti Research^™ - A Croda Brand
• stężenie: 10 mg/mL (710335C-25mg); 25 mg/mL (710335C-200mg); 25 mg/mL (710335C-500mg)
• typ lipidu: phospholipids; cardiolipins
• Warunki transportu: dry ice
• temp. przechowywania: −20°C

Opis

Opis ogólny

Cardiolipin has two phosphatidyl residues linked by glycerol.[1] 18:1 Cardiolipin or tetraoleoyl cardiolipin (TOCL) is a monounsaturated phospholipid[2] present in mitochondria.[3] TOCL bilayers have a larger hydrocarbon chain thickness compared to dioleoyl phosphatidylcholine (DOPC) bilayer.[4]

Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane,[5] which makes up to 20% of total lipids.[6] Cardiolipin is a non-bilayer anionic phospholipid, which possesses four acyl chains and a small headgroup.[7]

Cardiolipin is an anionic phospholipid.[7]

Zastosowanie

18:1 Cardiolipin has been used as a lipid standard in radiolabeling assay.[8]

18:1 Cardiolipin has been used for preparing solubilized lipids to assemble nanodiscs.[9][10]

18:1 Cardiolipin has been used:

• in liposome preparation for reconstituting yeast AAA ATPase protein, Msp1[11]
• in in vitro translation system for RNA transfection[10]
• as a synthetic lipid component to mimic mitochondrial inner membrane[12]

Działania biochem./fizjol.

Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy.[13] CL is essential for mitochondrial functions and apoptosis.[14] Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.[15]

Cardiolipin is involved in the dynamic organization of membranes and in cell division.[16] It modulates the proton uptake pathway.[7] Cardiolipin plays a critical role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It controls cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.[17]

Cardiolipin participates in proton uptake pathway and also maintains the structure of enzymes involved.[7] Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.

Opakowanie

5 mL Clear Glass Sealed Ampule (710335C-200mg)

5 mL Clear Glass Sealed Ampule (710335C-25mg)

5 mL Clear Glass Sealed Ampule (710335C-500mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06,GHS08
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• Zwroty wskazujące środki ostrożności: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Klasyfikacja zagrożeń: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Organy docelowe: Central nervous system, Liver,Kidney
• Kod klasy składowania: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): does not flash
• Temperatura zapłonu (°C): does not flash