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Merck

890890P

Avanti

18:1 TAP (DOTAP)

Avanti Research - A Croda Brand

Synonym(e):

1,2-dioleoyl-3-trimethylammonium-propane (chloride salt), DOTAP

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About This Item

Empirische Formel (Hill-System):
C42H80NO4Cl
CAS-Nummer:
Molekulargewicht:
698.54
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

powder

Verpackung

pkg of 1 × 1 g ((890890P-1G))
pkg of 2 × 100 mg ((890890P-200MG))
pkg of 5 × 100 mg ((890890P-100MG))
pkg of 1 × 25 mg ((890890P-25MG))

Hersteller/Markenname

Avanti Research - A Croda Brand

Anwendung(en)

advanced drug delivery

Lipid-Typ

transfection
cationic lipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

InChI

1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

InChIKey

KSXTUUUQYQYKCR-LQDDAWAPSA-M

Anwendung

18:1 TAP (DOTAP) has been used in chloroform solutions to form dry film in the preparation of cationic liposomes. It has also been used in standard stock solution used for the preparation of cationic liposomes.

Biochem./physiol. Wirkung

DOTAP (1,2-dioleoyl-3-trimethylammonium-propane) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP. DOTAP mediates gene knockdown technique in hematopoietic stem cells (HSCs).

Verpackung

5 mL Clear Glass Sealed Ampule (890890P-200mg)
5 mL Clear Glass Sealed Ampule (890890P-25mg)
5 mL Clear Glass Sealed Ampule (890890P-500mg)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (890890P-1g)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

auch häufig zusammen mit diesem Produkt gekauft

Produkt-Nr.
Beschreibung
Preisangaben

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis
Li Y, et al.
BMC Pharmacology & Toxicology, 19(1), 43-43 (2018)
Analysis of cationic liposomes by reversed-phase HPLC with evaporative light-scattering detection
Zhong Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 51(4), 947-951 (2010)
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
Elias J Sayour et al.
Nano letters, 18(10), 6195-6206 (2018-09-28)
Translation of nanoparticles (NPs) into human clinical trials for patients with refractory cancers has lagged due to unknown biologic reactivities of novel NP designs. To overcome these limitations, simple well-characterized mRNA lipid-NPs have been developed as cancer immunotherapeutic vaccines. While
Hojun Kim et al.
ACS nano, 12(9), 9196-9205 (2018-08-08)
The success of gene technologies hinges on our ability to engineer superior encapsulation and delivery vectors. Cubosomes are lipid-based nanoparticles where membranes, instead of enveloping into classic liposomes, intertwine into complex arrays of pores well-ordered in a cubic lattice. These

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