추천 제품
양식
powder
포장
pkg of 1 × 25 mg (860514P-25mg)
pkg of 1 × 5 mg (860514P-5mg)
제조업체/상표
Avanti Research™ - A Croda Brand 860514P
지질 유형
sphingolipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C32H63NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h25,27,30-31,34-35H,3-24,26,28-29H2,1-2H3,(H,33,36)/b27-25+/t30-,31+/m0/s1
InChI key
ZKRPGPZHULJLKJ-JHRQRACZSA-N
일반 설명
Ceramide synthesis is majorly driven by de novo pathway involving the palmitoyl-CoA and L-serine, and also by salvage pathway via recycling of complex sphingolipids.[1] The ceramide transporter, Cert mediates the transfer of C14 from smooth endoplasmic reticulum to Golgi.[1] Ceramide synthase CerS6 enzyme is involved in the synthesis of C14 ceramide.[2]
애플리케이션
C14 Ceramide (d18:1/14:0) is suitable for use
- as a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS2) for ceramide quantification from muscel biopsies[3]
- in lipid monolayer preparation for biophysical studies[4]
- in the morphological and dimensional evaluation studies[5]
생화학적/생리학적 작용
Ceramides regulate biological processes including proliferation, differentiation and apoptosis.[5] In the cystic fibrosis patients, elevated levels of C14 ceramide is observed.[1] It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio.[6] Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation.[2]
포장
5 mL Amber Glass Screw Cap Vial (860514P-25mg)
5 mL Amber Glass Screw Cap Vial (860514P-5mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
또한 이 제품과 함께 일반적으로 구입
제품 번호
설명
가격
Storage Class Code
11 - Combustible Solids
가장 최신 버전 중 하나를 선택하세요:
이미 열람한 고객
Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain
Garic D, et al.
Progress in Lipid Research (2019)
Ceramide N-acyl chain length: a determinant of bidimensional transitions, condensed domain morphology, and interfacial thickness
Dupuy F, et al.
Langmuir, 27(7), 3783-3791 (2011)
Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14: 0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity
Maldonado-Hernandez J, et al.
Canadian journal of gastroenterology & hepatology, 2017 (2017)
Tumor necrosis factor-alpha(TNFalpha)-induced ceramide generation via ceramide synthases regulates loss of focal adhesion kinase (FAK) and programmed cell death
Hernandez-Corbacho M, et al.
The Journal of Biological Chemistry, 290(42), 25356-25373 (2015)
Ceramide effects in the bicelle structure
Barbosa-Barros L, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 317(1-3), 576-584 (2008)
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