This product is a Quality Level 200. Methods of preparation are considered proprietary for products of this Quality Level. The product is listed as a synthetic, non-animal source material. See the link below to review a sample Certificate of Origin:
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COO/Q12/U1128-BULKSLCM8881.pdf
U1128
ウラシル
BioReagent, suitable for cell culture
別名:
2,4(1H,3H)-ピリミジンジオン, 2,4-ジヒドロキシピリミジン, 2,4-ピリミジンジオール
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25 G
￥6,146
100 G
￥11,900
About This Item
実験式（ヒル表記法）:
C4H4N2O2
CAS番号:
分子量:
112.09
Beilstein:
507828
EC Number:
MDL番号:
UNSPSCコード:
12352207
PubChem Substance ID:
NACRES:
NA.75
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由来生物
synthetic (organic)
品質水準
製品種目
BioReagent
アッセイ
≥99% (HPLC)
フォーム
powder
テクニック
cell culture | mammalian: suitable
mp
>300 °C (lit.)
溶解性
1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
保管温度
room temp
SMILES記法
O=C1NC=CC(=O)N1
InChI
1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChI Key
ISAKRJDGNUQOIC-UHFFFAOYSA-N
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詳細
Uracil belongs to the pyrimidine nucleobase family. It is naturally occurring and is an important and active part of RNA.[1]
アプリケーション
生物化学的／生理学的作用
Uracil and its derivatives play an integral part in medicinal chemistry for the synthesis of cancer, viral infections, autosomal recessive disorder, thyroid, and diabetic drugs.[1]
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
U1128-VAR:
U1128-BULK:
U1128-5G:
U1128-500G:
U1128-25G:
U1128-100G:
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試験成績書（COA）
Lot/Batch Number
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Deepthi Ramesh et al.
European journal of medicinal chemistry, 207, 112801-112801 (2020-09-15)
Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine nucleobase forms an integral part of many commercial drugs. Though the name uracil is usually associated with cancer drugs, there are many uracil-based compounds which can
Brian T Wilhelm et al.
Nature protocols, 5(2), 255-266 (2010-02-06)
Next-generation sequencing technologies are revolutionizing genomics research. It is now possible to generate gigabase pairs of DNA sequence within a week without time-consuming cloning or massive infrastructure. This technology has recently been applied to the development of 'RNA-seq' techniques for
Sandra M Carvalho et al.
PloS one, 8(3), e58492-e58492 (2013-03-19)
Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains
Daisuke Katagiri et al.
Journal of the American Society of Nephrology : JASN, 24(12), 2034-2043 (2013-10-05)
Accumulating evidence of the beyond-glucose lowering effects of a gut-released hormone, glucagon-like peptide-1 (GLP-1), has been reported in the context of remote organ connections of the cardiovascular system. Specifically, GLP-1 appears to prevent apoptosis, and inhibition of dipeptidyl peptidase-4 (DPP-4)
Pietro Andreone et al.
Gastroenterology, 147(2), 359-365 (2014-05-14)
The interferon-free regimen of ABT-450 (a protease inhibitor), ritonavir, ombitasvir (an NS5A inhibitor), dasabuvir (a non-nucleoside polymerase inhibitor), and ribavirin has shown efficacy in patients with hepatitis C virus (HCV) genotype 1b infection-the most prevalent subgenotype worldwide. We evaluated whether
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Is this synthesized in in vitro or acell-derived product?
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