T9576

Picropodophyllotoxin

≥96% (HPLC), powder

• 別名: (5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, NSC 36407, PPP, Picropodophyllin
• 実験式（ヒル表記法）: C₂₂H₂₂O₈
• CAS番号: 477-47-4
• 分子量: 414.41
• MDL番号: MFCD01742647
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826907
• NACRES: NA.77

特性

• アッセイ: ≥96% (HPLC)
• フォーム: powder
• 色: white
• 溶解性: DMSO: >5 mg/mL
• 保管温度: 2-8°C
• SMILES記法: COc1cc(cc(OC)c1OC)[C@H]2C3C(COC3=O)[C@@H](O)c4cc5OCOc5cc24
• InChI: 1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1
• InChI Key: YJGVMLPVUAXIQN-HAEOHBJNSA-N
• 遺伝子情報: human ... IGF1R(3480)

詳細

生物化学的／生理学的作用

Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP can induce G2-M cell cycle arrest even in IGF-IR deficient cells. Hence, the role of PPP in IGF-IR-mediated anticancer functions is debatable[1].

Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor.

特徴および利点

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

品質

May contain 2-3% ethanol (w/w)

調製ノート

Picropodophyllotoxin is soluble in DMSO at a concentration that is greater than 5 mg/ml.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H312,H315,H319,H335
• 注意書き: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges