SML1132

Pep2-8 trifluoroacetate salt

≥95% (HPLC), contains 58μL of solution at 10mM in DMSO

• 別名: Ac-TVFTSWEEYLDWV-NH₂ trifluoroacetate salt, Ac-TVFTSWEEYLDWV-amide trifluoroacetate salt, Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt
• 実験式（ヒル表記法）: C₈₃H₁₁₀N₁₆O₂₄ · xC₂HF₃O₂
• 分子量: 1715.85 (free base basis)
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• フォーム: solution
• 色: colorless to pale yellow
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

Amino Acid Sequence

Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH₂ trifluoroacetate salt

生物化学的／生理学的作用

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that selectively binds to PCSK9 and interferes with LDL receptor binding to PCSK9. Pep2-8 restores LDL receptor function and LDL uptake of PCSK9-treated HepG2 cells.

Pep2-8 is a potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor.

Pep2-8, a good mimic of epidermal growth factor precursor homology domain A (EGF-A)[1], serves as a competitive inhibitor of low-density lipoprotein (LDL) receptor binding.[2] It can be used as an anchor peptide in phage-display experiments to bind an extension peptide library to the groove site.[1]

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable