SML1035

ICA-121431

≥98% (HPLC)

• 別名: α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide
• 実験式（ヒル表記法）: C₂₃H₁₉N₃O₃S₂
• CAS番号: 313254-51-2
• 分子量: 449.55
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: room temp
• SMILES記法: [S](=O)(=O)(Nc4[s]ccn4)c1ccc(cc1)NC(=O)C(c3ccccc3)c2ccccc2
• InChI: 1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27)
• InChI Key: URSQNPPONHUJDL-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

ICA-121431 [2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl) acetamide, a small molecule inhibitor, targets the extracellular amino acids in S2 and S3 in VSDIV (domain IV voltage sensor), which is essential for Hm1a efficacy.[1] In humans, ICA-121431 blocks TTX-sensitive Na_v1.3 sodium channels upregulated in HEK-293 cells.[2]

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC₅₀ = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels.

ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H319,H413
• 注意書き: P273 - P301 + P312 + P330 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable