SBR00038

Hygromycin B

Min. 95% (HPLC ELSD), from Streptomyces hygroscopicus

• 実験式（ヒル表記法）: C₂₀H₃₇N₃O₁₃
• CAS番号: 31282-04-9
• 分子量: 527.52
• UNSPSCコード: 51281624
• NACRES: NA.76

特性

• 製品名: ハイグロマイシン B, from Streptomyces hygroscopicus
• 由来生物: Streptomyces hygroscopicus
• 品質水準: 200
• フォーム: solid
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria; fungi; viruses
• 作用機序: protein synthesis | interferes
• 保管温度: 2-8°C
• SMILES記法: N([C@@H]1[C@H]([C@@H]([C@H]([C@@H](C1)N)O)O[C@@H]2O[C@@H]([C@@H]([C@@H]3O[C@@]4(O[C@@H]32)O[C@@H]([C@@H]([C@@H]([C@H]4O)O)O)[C@H](N)CO)O)CO)O)C
• InChI: 1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
• InChI Key: GRRNUXAQVGOGFE-XKIAHZFYSA-N

詳細

詳細

Chemical structure: aminoglycoside

アプリケーション

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

生物化学的／生理学的作用

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300 + H310 + H330
• 注意書き: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• 危険有害性の分類: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable