SAB4501880

Anti-KI67 antibody produced in rabbit

affinity isolated antibody

• 別名: Antigen KI-67, MKI67
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 358 kDa
• 交差性: human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100
• NCBIアクセッション番号: P46013
• UniProtアクセッション番号: P46013
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... MKI67(4288)

詳細

詳細

Marker of proliferation Ki-67 (MKI67) is encoded by the gene mapped to human chromosome 10. The encoded protein is characterized by the phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal, 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.

免疫原

The antiserum was produced against synthesized peptide derived from human Ki67.

Immunogen Range: 3207-3256

アプリケーション

Anti-KI67, C-Terminal antibody produced in rabbit has been used in following studies:

• immunohistochemistry.[1][2][2][3]
• immunofluorescence staining.[4][3]
• western blotting[5]

生物化学的／生理学的作用

Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, function as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered as a potential cell proliferation marker.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable