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Merck
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安全性情報

LO4100

Sigma-Aldrich

LOPAC®1280－小スケール

別名:

Library of Pharmacologically Active Compounds - small scale

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About This Item

EC Number:
200-664-3
UNSPSCコード:
12352200
NACRES:
NA.77
製品LO4100は現在お客様の国では販売されていません。 製品に関するお問い合わせはこちら（テクニカルサービス）

形状

liquid

品質水準

100

輸送温度

dry ice

保管温度

−20°C

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詳細

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).
LOPAC® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.[1]

アプリケーション

LOPAC® 1280 - Small Scale has been used:
  • in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis[2][3]
  • for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay[1]
  • for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors[4]

特徴および利点

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apoptosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-Drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:
  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Product Number
  • Rack Position

その他情報

For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.

法的情報

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

ピクトグラム

Skull and crossbonesHealth hazardCorrosionEnvironment
GHS06,GHS08,GHS05,GHS09

シグナルワード

Danger

危険有害性の分類

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

保管分類コード

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

引火点(°F)

188.6 °F

引火点(℃)

87 °C

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

毒物及び劇物取締法

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PRTR

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消防法

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労働安全衛生法名称等を表示すべき危険物及び有害物

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労働安全衛生法名称等を通知すべき危険物及び有害物

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カルタヘナ法

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Jan Code

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試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Sara M Vliet et al.
Toxicology and applied pharmacology, 329, 241-248 (2017-06-18)
Spontaneous activity represents an early, primitive form of motor activity within zebrafish embryos, providing a potential readout for identification of neuroactive compounds. However, despite use as an endpoint in chemical screens around the world, the predictive power and limitations of
Roland E Kälin et al.
Blood, 114(5), 1110-1122 (2009-05-30)
Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor progression. Here we applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus
Miao Xu et al.
Nature medicine, 22(10), 1101-1107 (2016-08-30)
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug
Houtan Moshiri et al.
Journal of biomolecular screening, 20(1), 92-100 (2014-08-30)
Most mitochondrial messenger RNAs in trypanosomatid pathogens undergo a unique type of posttranscriptional modification involving insertion and/or deletion of uridylates. This process, RNA editing, is catalyzed by a multiprotein complex (~1.6 MDa), the editosome. Knockdown of core editosome proteins compromises
Jaime Freitas et al.
Current chemical genomics and translational medicine, 8, 36-46 (2014-04-29)
To adapt the use of GH3.TRE-Luc reporter gene cell line for a quantitative high-throughput screening (qHTS) platform, we miniaturized the reporter gene assay to a 1536-well plate format. 1280 chemicals from the Library of Pharmacologically Active Compounds (LOPAC) and the
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資料

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

LOPAC®1280低分子化合物ライブラリースクリーニング

化合物ライブラリースクリーニングに関する理解を深めて、Library of Pharmacologically Active Compounds（LOPAC®1280）を含む化合物ライブラリーをご覧いただき、生物学的注釈付きのすぐにスクリーニング可能な化合物のゴールドスタンダードコレクションを体験してください。

質問

1–9/9 質問  

  1. What is the difference between the LOPAC1280 Products LO4100 and LO4200?

    1 回答

    1. These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.

      役に立ちましたか？

  2. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200  US approved?

    1 回答

    1. About 30% of the collection is made up of drugs approved for use in the US.

      役に立ちましたか？

  3. Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    1 回答

    1. There is no CAS number list available.

      役に立ちましたか？

  4. What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?

    1 回答

    1. The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.

      役に立ちましたか？

  5. What is the difference between the LOPAC®,1280 product numbers LO4100 and LO1280?

    1 回答

    1. The compound per well in LO4100 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280

      役に立ちましたか？

  6. Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?

    1 回答

    1. Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at [email protected] or 1800-325-5832.

      役に立ちましたか？

  7. What is the Department of Transportation shipping information for this product?

    1 回答

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      役に立ちましたか？

  8. Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    1 回答

    1. The information is available in the datasheet of a similar product LO1280.

      役に立ちましたか？

  9. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?

    1 回答

    1. Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.

      役に立ちましたか？

レビュー

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アクティブなフィルタ

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