I3159

IMD-0354

≥98% (HPLC), solid

• 別名: N-(3,5-ビス-トリフルオロメチルフェニル)-5-クロロ-2-ヒドロキシベンズアミド
• 実験式（ヒル表記法）: C₁₅H₈ClF₆NO₂
• CAS番号: 978-62-1
• 分子量: 383.67
• MDL番号: MFCD00218820
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724513
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 溶解性: DMSO: >20 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: Oc1ccc(Cl)cc1C(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
• InChI: 1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
• InChI Key: CHILCFMQWMQVAL-UHFFFAOYSA-N

詳細

アプリケーション

IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2.[1] It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.[2]

生物化学的／生理学的作用

IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus.[3] It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth.[3] IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. ^[4]

包装

光感受性です。窒素充填しています。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves