G0544

GR 103691

≥98% (HPLC), solid

• 別名: 4'-アセチル-N-[4-[4-(2-メトキシフェニル)-1-ピペラジニル]ブチル]-[1,1'-ビフェニル]-4-カルボキサミド
• 実験式（ヒル表記法）: C₃₀H₃₅N₃O₃
• CAS番号: 162408-66-4
• 分子量: 485.62
• MDL番号: MFCD00936840
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724488
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 色: white
• 溶解性: DMSO: soluble >5 mg/mL at 60 °C
• オーガナイザー: GlaxoSmithKline
• 保管温度: 2-8°C
• SMILES記法: COc1ccccc1N2CCN(CCCCNC(=O)c3ccc(cc3)-c4ccc(cc4)C(C)=O)CC2
• InChI: 1S/C30H35N3O3/c1-23(34)24-9-11-25(12-10-24)26-13-15-27(16-14-26)30(35)31-17-5-6-18-32-19-21-33(22-20-32)28-7-3-4-8-29(28)36-2/h3-4,7-16H,5-6,17-22H2,1-2H3,(H,31,35)
• InChI Key: JARNORYOPMINDY-UHFFFAOYSA-N
• 遺伝子情報: rat ... Htr1a(24473)

詳細

アプリケーション

GR 103691 has been used as a D3 receptor antagonist to test its:

• inducing effect on prepulse inhibition (PPI)[1]
• suppressive effect of motor behavior in rats[2]
• inhibitory effect on chemotaxis in newly excysted juvenile C. sinensis (CsNEJs)[3]

生物化学的／生理学的作用

D₃ド-パミンレセプタ-アンタゴニスト。

GR 103691 increases the monosynaptic “stretch” reflex (MSR) amplitude in mice by its potent D3 receptor antagonist functionality.[4] It inhibits the PD 128,907 mediated γ-aminobutyric acid (GABA) release.[5]

特徴および利点

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法的情報

Glaxo­Smith­Klineとの合意に基づき、研究目的用として販売しています。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)