P6402

ペルフェナジン

• 別名: 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
• 実験式（ヒル表記法）: C₂₁H₂₆ClN₃OS
• CAS番号: 58-39-9
• 分子量: 403.97
• NACRES: NA.77
• PubChem Substance ID: 24278642
• UNSPSC Code: 12352200
• EC Number: 200-381-5
• MDL number: MFCD00056798
• Form: powder

特性

• form: powder
• Quality Segment: 200
• originator: Schering Plough
• storage temp.: 2-8°C
• SMILES string: ClC(C=C1)=CC2=C1SC3=CC=CC=C3N2CCCN4CCN(CCO)CC4
• InChI: 1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
• InChI key: RGCVKNLCSQQDEP-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), DRD2(1813), OPRS1(10280)

詳細

General description

Perphenazine is an antipsychotic drug used in treating schizophrenia. It modulates antioxidant levels and helps in the management of oxidative injury in schizophrenia. However, it is less effective than the clozapine drug group in improving response to oxidative injury.

Biochem/physiol Actions

D₂ド-パミンレセプタ-のアンタゴニストです。αアドレナリン作動性受容体アンタゴニストであり、σ受容体アゴニストです。フェノチアジン系抗精神病薬です。in vitroでグルタミン酸デヒドロゲナ-ゼを阻害します。

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• 注意喚起語: Warning
• ハザードコード: H302,H317
• 注意事項: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1
• 保管分類: 11 - Combustible Solids
• WGK: WGK 3