There is no solubility testing for F6627 in water during quality control testing. The product is tested at 50 mg/ml in 1 M Ammonium Hydroxide. Product 343922 is tested for solubility at 5mg/ml in DMF and DMSO. The product is also tested at 1 mg/ml in hot water. Hot can be up to about 95°C. It should be noted that no solution stability studies have been performed on solutions heated to 95°C.
The Product Information Sheet for F6627 lists solution stability at 37°C for 7 days only. Solutions at 25°C are stable for several weeks. Solutions stored at 0-4°C are stable for at least 4 months. The product information for 343922 states stock solutions are stable up to 3 months at -20°C. Solubility in aqueous solutions increases with pH. The trend in storage temperatures shows decreased solution stability with increasing temperature.
Different sources will give widely varying solubility information for 5 Fluorouracil. The solubility guarantee for F6627 is listed on the Specification Sheet/Certificate of Analysis as 50mg/ml in 1M NaOH. The guarantees for 343922 are DMF (5 mg/ml), DMSO (5 mg/ml), Methanol (1 mg/ml), or hot H?O (1 mg/ml). Claims made by other suppliers are not guaranteed.
