D9150

2,3-ジメトキシ-5-メチル-p-ベンゾキノン

apoptosis inducer

• 別名: コエンザイムQ₀
• 実験式（ヒル表記法）: C₉H₁₀O₄
• CAS番号: 605-94-7
• 分子量: 182.17
• Beilstein: 1640422
• EC Number: 210-100-8
• MDL番号: MFCD00001595
• UNSPSCコード: 12352204
• PubChem Substance ID: 24894261
• NACRES: NA.51

特性

• フォーム: powder
• mp: 58-60 °C (lit.)
• 保管温度: 2-8°C
• SMILES記法: COC1=C(OC)C(=O)C(C)=CC1=O
• InChI: 1S/C9H10O4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4H,1-3H3
• InChI Key: UIXPTCZPFCVOQF-UHFFFAOYSA-N

詳細

詳細

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀ or DMM) is present in all the cells including neural cells.[1]

アプリケーション

2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:

• as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)[2]
• as a component in buffer B for cytochrome oxidation assay with subsaturating light[3]
• in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity[4]

Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.

生物化学的／生理学的作用

2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q₀) interacts with tau protein and aids in the formation of filamentous structure.[1]

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves