C7291

クロミプラミン 塩酸塩

≥98% (HPLC), powder

• 別名: 3-クロロ-10,11-ジヒドロ-N,N-ジメチル-5H-ジベンゾ[b,f]アゼピン-5-プロパンアミン 塩酸塩, アナフラニール 塩酸塩
• 実験式（ヒル表記法）: C₁₉H₂₃ClN₂ · HCl
• CAS番号: 17321-77-6
• 分子量: 351.31
• EC Number: 241-344-3
• MDL番号: MFCD00069234
• UNSPSCコード: 12352116
• PubChem Substance ID: 24278087
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to off-white
• 溶解性: H₂O: 25 mg/mL; 0.1 M HCl: soluble
• オーガナイザー: Novartis
• SMILES記法: Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
• InChI: 1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
• InChI Key: WIMWMKZEIBHDTH-UHFFFAOYSA-N
• 遺伝子情報: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

詳細

詳細

Clomipramine hydrochloride is an antiobsessional drug.[1] It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.[2]

アプリケーション

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms.[3] It has also been used to study its role on bone mass.[4]

Clomipramine hydrochloride has been used:

• to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques[5]
• to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation[6]
• as a serotonin reuptake inhibitor[7]
• as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor[8]

生物化学的／生理学的作用

Clomipramine hydrochloride (CLP) is a amphiphilic drug,[5] with two benzene rings in its structure.[9] It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.[5]

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

特徴および利点

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS08,GHS07,GHS09
• シグナルワード: Danger
• 危険有害性情報: H302,H336,H370,H410
• 注意書き: P260 - P264 - P271 - P273 - P301 + P312 - P308 + P311
• 危険有害性の分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
• ターゲットの組織: Central nervous system, Central nervous system,Cardiovascular
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves