M2525

ミアンセリン 塩酸塩

5-HT₂ serotonin receptor

• 別名: 1,2,3,4,10,14b-ヘキサヒドロ-2-メチル-ジベンゾ[c,f]ピラジノ[1,2-a]アゼピン 塩酸塩
• 実験式（ヒル表記法）: C₁₈H₂₀N₂ · HCl
• CAS番号: 21535-47-7
• 分子量: 300.83
• NACRES: NA.77
• PubChem Substance ID: 24278125
• UNSPSC Code: 12352200
• EC Number: 244-426-7
• MDL number: MFCD00055072

特性

• 製品名: ミアンセリン 塩酸塩,
• Quality Segment: 200
• solubility: H₂O: 3.4 mg/mL, ethanol: 5.6 mg/mL
• originator: Organon
• storage temp.: 2-8°C
• SMILES string: Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24
• InChI: 1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
• InChI key: YNPFMWCWRVTGKJ-UHFFFAOYSA-N
• Gene Information: human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)

詳細

Application

Mianserin hydrochloride has been used:

• as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)
• as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression
• as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation

Biochem/physiol Actions

Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.

Antidepressant; antagonist/inverse agonist at 5-HT₂ serotonin receptors; also blocks the H₁ histamine receptor and the α₂ adrenoceptor.

Features and Benefits

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

溶液は、4°Cで数日間は保存することができます。

安全性情報

• signalword: Warning
• pictograms: GHS07
• hcodes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• 保管分類: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves