I0899

イミプラミン 塩酸塩

BioXtra, ≥99% (TLC)

• 別名: 10,11-ジヒドロ-N,N-ジメチル-5H-ジベンゾ[b,f]アゼピン-5-プロパンアミン 塩酸塩, 5-[3-(ジメチルアミノ)プロピル]-10,11-ジヒドロ-5H-ジベンゾ[b,f]アゼピン 塩酸塩
• 実験式（ヒル表記法）: C₁₉H₂₄N₂ · HCl
• CAS番号: 113-52-0
• 分子量: 316.87
• NACRES: NA.25
• PubChem Substance ID: 24895912
• UNSPSC Code: 12352116
• EC Number: 204-030-7
• MDL number: MFCD00012669
• Assay: ≥99% (TLC)
• Form: powder

特性

• product line: BioXtra
• Quality Segment: 200
• assay: ≥99% (TLC)
• form: powder
• impurities: ≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter
• ign. residue: ≤0.1%
• solubility: H₂O: 50 mg/mL, colorless to faintly yellow
• anion traces: sulfate (SO₄^2-): ≤0.05%
• cation traces: Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.005%, K: ≤0.005%, Mg: ≤0.0005%, NH₄⁺: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI key: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• Gene Information: human ... SLC6A2(6530), SLC6A4(6532)

詳細

Application

• Novel, fast, and reliable electrochemical dsDNA biosensor based on O-terminated pristine nanocrystalline boron-doped diamond electrode for DNA interaction studies.: Research featuring a novel electrochemical dsDNA biosensor that facilitates the study of DNA interactions with imipramine hydrochloride, enhancing our understanding of its genotoxic effects and providing crucial insights for biochemistry applications (Augustín M et al., 2024).


• Comparison of two pharmacological protocols for inducing ex copula ejaculation in donkeys.: In this comparative study, imipramine hydrochloride is used within a pharmacological protocol, offering significant insights into veterinary applications and animal reproductive studies (Khan FA et al., 2024).


• Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with p-Benzoquinones.: This publication outlines a novel spectrophotometric method for analyzing tricyclic antidepressants like imipramine hydrochloride, providing an efficient tool for quantitative analysis in pharmaceutical and clinical research (Ciuca MD et al., 2023).

Biochem/physiol Actions

三環系抗うつ剤です。セロトニン輸送体、ノルエピネフリン輸送体を阻害します (各K_i値は7.7 nM、67 nM)。ド-パミン輸送体にはほとんど影響しません (K_i=25 μM)。

三環系抗うつ剤です。セロトニン輸送体およびノルエピネフリン輸送体を阻害します。ド-パミン輸送体にはほとんど影響しません。

安全性情報

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• 保管分類: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• flash_point_f: Not applicable
• flash_point_c: Not applicable