V8388

Vincristine 硫酸

meets USP testing specifications

• 別名: ビンクリスチン 硫酸塩, 22-オキソビンカロイコブラスチン 硫酸塩, VCR, ロイロクリスチン 硫酸塩
• 実験式（ヒル表記法）: C₄₆H₅₆N₄O₁₀ · H₂SO₄
• CAS番号: 2068-78-2
• 分子量: 923.04
• Beilstein: 3924631
• EC Number: 218-190-0
• MDL番号: MFCD00084729
• UNSPSCコード: 12352210
• PubChem Substance ID: 24900771
• NACRES: NA.21

特性

• 認証: USP/NF; meets USP testing specifications
• 品質水準: 200
• 溶解性: ethanol: slightly soluble; methanol: soluble; water: freely soluble
• 抗生物質活性スペクトル: neoplastics
• アプリケーション: pharmaceutical (small molecule)
• 作用機序: protein synthesis | interferes
• 保管温度: −20°C
• SMILES記法: OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
• InChI Key: AQTQHPDCURKLKT-PNYVAJAMSA-N

詳細

詳細

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.[1]

アプリケーション

Vincristine sulfate has been used:

• as a positive control in potato disc anti-tumor bioassay[2]
• as a standard cytotoxic agent[3]
• to treat cells for manipulation of the microtubule network[4]

Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).

生物化学的／生理学的作用

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.[1]

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H300,H341,H361fd
• 注意書き: P202 - P264 - P270 - P280 - P301 + P310 - P405
• 危険有害性の分類: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)