PHR1782

ヒドロキシクロロキン硫酸塩

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 7-クロロ-4-[4-(N-エチル-N-b-ヒドロキシエチルアミノ)-1-メチルブチルアミノ]キノリン硫酸塩
• 実験式（ヒル表記法）: C₁₈H₂₆ClN₃O · H₂SO₄
• CAS番号: 747-36-4
• 分子量: 433.95
• EC Number: 212-019-3
• MDL番号: MFCD00078203
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823611
• NACRES: NA.24

特性

• 由来生物: synthetic
• 品質水準: 300
• グレード: certified reference material; pharmaceutical secondary standard
• 認証: BP; EP; USP; traceable to BP 1100; traceable to USP 1327000
• APIファミリー: hydroxychloroquine
• 形状: powder or crystals
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• 保管条件: protect from light
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 色: white to off-white
• pH: 3.5-5.5 (1% in aqueous solution, pH <6.0)
• mp: 238-241 °C
• 溶解性: chloroform: practically insoluble; ethanol: practically insoluble; ether: practically insoluble; water: soluble
• アプリケーション: pharmaceutical (small molecule)
• 輸送温度: ambient
• 保管温度: 2-30°C
• SMILES記法: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• InChI Key: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• 遺伝子情報: human ... TLR7(51284) , TLR9(54106)

詳細

詳細

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Hydroxychloroquine Sulfate can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

ヒドロキシクロロキン硫酸塩は、抗炎症性（TNFを介する）の疾患修飾性抗リウマチ薬（DMARD）であり、ヘムポリメラーゼ阻害剤です。 マラリアの治療に使用されます。

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC0287 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319
• 注意書き: P301 + P312 + P330 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable