This product is soluble in ethanol, methanol, acetone, ether, acetonitrile, and chloroform. This product is a reference standard intended for use in laboratory chemical testing, primarily per compendial monographs. This product may not be used for therapeutic or diagnostic purposes in humans or animals. Please contact your regional Technical Service group for assistance with specific applications.
PHR1092
シクロスポリン
Pharmaceutical Secondary Standard; Certified Reference Material
別名:
シクロスポリンA, シクロスポリン, 抗生物質 S 7481F1
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500 MG
￥37,700
About This Item
実験式（ヒル表記法）:
C62H111N11O12
CAS番号:
分子量:
1202.61
Beilstein:
3647785
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:
NACRES:
NA.24
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グレード
certified reference material
pharmaceutical secondary standard
品質水準
認証
traceable to Ph. Eur. C2163000
traceable to USP 1158504
APIファミリー
cyclosporine
CofA
current certificate can be downloaded
テクニック
HPLC: suitable
gas chromatography (GC): suitable
アプリケーション
pharmaceutical (small molecule)
フォーマット
neat
保管温度
-10 to -25°C
SMILES記法
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI Key
PMATZTZNYRCHOR-CGLBZJNRSA-N
遺伝子情報
human ... PPIA(5478)
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関連するカテゴリー
詳細
Cyclosporine is a lipophilic immunosuppressive peptide with antifungal and anti-inflammatory properties.[1] It selectively inhibits the production of cytokines involved in T-lymphocyte activation in response to antigen stimulation.[2] It is widely used to prevent transplanted organ rejection and for the treatment of various autoimmune diseases.[3]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
アプリケーション
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
Cyclosporine may be used as a reference standard for the determination of cyclosporine in biological samples by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method.[4]
生物化学的／生理学的作用
強力な免疫抑制特性を有する真菌代謝物です。カルシニュ-リン (プロテインホスファタ-ゼ2B) を阻害するシクロスポリン-シクロフィリン複合体の形成を介して、T細胞シグナル伝達経路を阻害します。インタ-ロイキン1α、リポ多糖、TNFαにより誘導される一酸化窒素合成を阻害します。ミトコンドリアからのチトクロ-ムCの放出を遮断します。
強力な免疫抑制薬で、インタ-ロイキン1α、リポ多糖、TNFαにより誘導される一酸化窒素合成を阻害します。ミトコンドリアからのチトクロ-ムCの放出を遮断します。
アナリシスノート
このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。
その他情報
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
脚注
To see an example of a Certificate of Analysis for this material enter LRAB3757 in the slot below. This is an example certificate only and may not be the lot that you receive.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
保管分類コード
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
30024-25MG-PW:
30024-25MG:
PHR1092-500MG:
30024-100MG:
30024-BULK:
30024-VAR:
PHR1092-500MG-BULK:
PHR1092-500MG-PW:
30024-100MG-PW:
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Tip W Loo et al.
Biochemistry, 52(41), 7167-7169 (2013-10-03)
There is no high-resolution crystal structure of the human P-glycoprotein (P-gp) drug pump. Homology models of human P-gp based on the crystal structures of mouse or Caenorhabditis elegans P-gps show large differences in the orientation of transmembrane segment 5 (TM5).
Jane Rasaiyaah et al.
Nature, 503(7476), 402-405 (2013-11-08)
Human immunodeficiency virus (HIV)-1 is able to replicate in primary human macrophages without stimulating innate immunity despite reverse transcription of genomic RNA into double-stranded DNA, an activity that might be expected to trigger innate pattern recognition receptors. We reasoned that
Angela C Webster et al.
BMJ (Clinical research ed.), 331(7520), 810-810 (2005-09-15)
To compare the positive and negative effects of tacrolimus and ciclosporin as initial treatment for renal transplant recipients. Systematic review. Reports of comparative randomised trials of tacrolimus and ciclosporin identified by searches of Medline, Embase, the Cochrane Register of Controlled
David A Williams et al.
Pediatric blood & cancer, 61(5), 869-874 (2013-11-29)
Randomized clinical trials in pediatric aplastic anemia (AA) are rare and data to guide standards of care are scarce. Eighteen pediatric institutions formed the North American Pediatric Aplastic Anemia Consortium to foster collaborative studies in AA. The initial goal of
Koichi Watashi et al.
Hepatology (Baltimore, Md.), 59(5), 1726-1737 (2014-01-01)
Chronic hepatitis B virus (HBV) infection is a major public health problem worldwide. Although nucleos(t)ide analogs inhibiting viral reverse transcriptase are clinically available as anti-HBV agents, emergence of drug-resistant viruses highlights the need for new anti-HBV agents interfering with other
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What is the concentration of this substance?
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This material is in powder form. The purity is typically greater than 99% and is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate.
https://www.sigmaaldrich.com/product/sial/phr1092#product-documentation役に立ちましたか？
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