8.17073

Fumaric acid

EMPROVE^® ESSENTIAL, NF, JPE

• 別名: Fumaric acid, trans-1,2-Ethylentricarboxylic acid
• 実験式（ヒル表記法）: C₄H₄O₄
• CAS番号: 110-17-8
• 分子量: 116.07
• MDL番号: MFCD00002700
• UNSPSCコード: 12352106
• EC Index Number: 203-743-0

特性

• 認証: JPE; NF
• 品質水準: 500
• 蒸気圧: <0.001 hPa ( 20 °C)
• 製品種目: EMPROVE^® ESSENTIAL
• 形状: solid
• 自己発火温度: 375 °C
• 有効性: 9300 mg/kg LD₅₀, oral (Rat); 20000 mg/kg LD₅₀, skin (Rabbit)
• テクニック: API processing | cocrystal formation: suitable; API processing | salt formation: suitable
• pH: 2.1 (20 °C, 4.9 g/L in H₂O)
• bp: 290 °C/1013 hPa (sublimed)
• mp: 287 °C
• 転移温度: flash point 273 °C
• 溶解性: 4.9 g/L
• 密度: 1.64 g/cm³ at 20 °C
• アプリケーション: liquid formulation; pharmaceutical; solid formulation
• 保管温度: 15-25°C
• InChI: 1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
• InChI Key: VZCYOOQTPOCHFL-OWOJBTEDSA-N

詳細

詳細

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

アプリケーション

Fumaric acid is a commonly used ingredient in both food and pharmaceutical applications. In pharmaceutical applications, fumaric acid has been used primarily as a pH modifier.

法的情報

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): 523.4 °F
• 引火点(℃): 273 °C