582231

Tetanus Toxoid

from Clostridium tetani, , lyophilized, nontoxic antigenic agent, Calbiochem^®

• 別名: TTx
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Tetanus Toxoid, Clostridium tetani, This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD₅₀ in mice.
• 品質水準: 200
• フォーム: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

Tetanus Toxoid belongs to the vaccine class of medications. Useful for immunization against tetanus and wound prophylaxis. Non-toxic as determined by an LD50 assay in mice.

アプリケーション

Tetanus Toxoid, Clostridium tetani has been used: as a positive-control antigen used to assess antibodies against different SARS-CoV-2 proteins and peptides in patients[1]; to assess lymphocyte proliferation in rabbit PBMC cultures in response to recall antigen stimulation[2]; a stimulus for PBMCs from chronic HBV carrier donors in a T cell proliferation assay[3]

生物化学的／生理学的作用

Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.

特徴および利点

• Prepared by formaldehyde inactivation of tetanus toxin.
• Prepared by formaldehyde inactivation of tetanus toxin.
• Toxoid retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
• Cell permeable: no
• Product does not compete with ATP.
• Reversible: no

警告

Toxicity: Standard Handling (A)

物理的形状

Lyophilized from 100 mM histidine, 100 mM NaCl, 5% trehalose, pH 7.0.

再構成

Reconstitute in 50 µl of sterile distilled H₂O

その他情報

Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable