567630

Sodium Salicylate

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

• 別名: Sodium Salicylate, Salicylic Acid, Na, NaSal
• 実験式（ヒル表記法）: C₇H₅O₃ · Na
• CAS番号: 54-21-7
• 分子量: 160.10
• MDL番号: MFCD00002440
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• 詳細: Merck USA index - 14, 8332
• アッセイ: ≥98% (titration)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: off-white
• 溶解性: water: 50 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• SMILES記法: [Na+].[O-]C(=O)c1c(cccc1)O
• InChI: 1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
• InChI Key: ABBQHOQBGMUPJH-UHFFFAOYSA-M

詳細

詳細

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

A non-steroidal, anti-inflammatory drug that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H319,H361d
• 注意書き: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): 208.9 °F - Pensky-Martens closed cup
• 引火点(℃): 98.3 °C - Pensky-Martens closed cup