If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
A5376
アセチルサリチル酸
≥99.0%
別名:
2-アセトキシ安息香酸, O-アセチルサリチル酸, ASA, アスピリン
サイズを選択してください
| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|
この商品について
biological source
synthetic
Quality Segment
assay
≥99.0%
form
powder
color
white
pKa (25 °C)
3.5
mp
134-136 °C (lit.)
solubility
H2O: 10 mg/mL at 37 °C(lit.), H2O: 3 mg/mL at 25 °C(lit.), ethanol: 50 mg/mL, aqueous base: decomposes
ε (extinction coefficient)
190 at 298 nm in aqueous base at 1 mM, 409 at 231 nm in aqueous base at 1 mM, 466 at 230 nm in aqueous acid at 1 mM, 68 at 278 nm in aqueous acid at 1 mM
SMILES string
CC(=O)Oc1ccccc1C(O)=O
InChI
1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChI key
BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Gene Information
human ... ITGA2B(3674), ITGB3(3690), PTGS1(5742), PTGS2(5743)
General description
Biochem/physiol Actions
1 of 1
当該品目 | |||
|---|---|---|---|
| assay ≥99.0% | assay - | assay - | assay - |
| biological source synthetic | biological source - | biological source - | biological source - |
| Gene Information human ... ITGA2B(3674), ITGB3(3690), PTGS1(5742), PTGS2(5743) | Gene Information human ... PTGS1(5742), PTGS2(5743) | Gene Information human ... PTGS1(5742), PTGS2(5743) | Gene Information human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743) |
| Quality Level 200 | Quality Level - | Quality Level - | Quality Level 200 |
| form powder | form - | form - | form powder or crystals |
| solubility H2O: 10 mg/mL at 37 °C(lit.), ethanol: 50 mg/mL, H2O: 3 mg/mL at 25 °C(lit.), aqueous base: decomposes | solubility - | solubility - | solubility - |
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signalword
Warning
保管分類
11 - Combustible Solids
flash_point_f
482.0 °F
flash_point_c
250 °C
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
名称等を表示すべき危険物及び有害物
ishl_indicated
名称等を通知すべき危険物及び有害物
ishl_notified
A5376-1KG:4.548173947013E12 + A5376-100G:4.548173947006E12 + A5376-500G:4.548173947037E12 + A5376-250G:4.54817394702E12
jan
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How can I determine the shelf life / expiration / retest date of this product?
1 回答-
役に立ちましたか？
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This product, A5376, could be used for cell culture ? What about the stability of the product ?
1 回答-
In the original sealed container, this material is quited stable and assigned a retest date of 5 years from the date of Quality Release. The retest date is lot specific and published in the Certificate of Analysis. In aqueous solution, Acetylsalicylic acid is hydrolyzed gradually to salicylic acid. Please see the link below to review a publication ragarding the half-life in solution:
https://www.sciencedirect.com/science/article/pii/S0095955315360510This product has not been tested for suitability in cell culture. However, researchers have cited using this product for cell culture applications. Please see the links below to review published examples:
https://www.nature.com/articles/s41467-017-00259-3
https://www.sciencedirect.com/science/article/pii/S0887233302001285役に立ちましたか？
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 回答-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
役に立ちましたか？
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could you please tell me what is the stability of aspirin (cat #5376) once recnstituted in PBS please?
1 回答-
Aqueous solutions of acetylsalicylic acid will readily hydrolyze to form salicylic acid. Solutions are most stable at pH 2 - 3, but to assure full activity, solutions should be freshly prepared. Please see the link below to review a publication on the compound stability:
https://intapi.sciendo.com/pdf/10.1515/cipms-2016-0009役に立ちましたか？
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How does aspirin act as an anticlotting agent?
1 回答-
There may be multiple modes of action which result in the anticlotting properties of aspirin. Some studies have indicated a decrease in thrombin levels and others reduced clotting properties of fibrinogen.
役に立ちましたか？
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Is Product A5376, Acetylsalicylic acid, offered by Sigma-Aldrich different from that found in aspirin tablets from the drug store?
1 回答-
The active ingredient acetylsalicylic acid offered by Sigma-Aldrich is the same chemical as found in aspirin tablets. However, chemicals for pharmaceutical use are manufactured, tested, and packaged under the regulation of the FDA, but chemicals sold for research use do not have the same regulatory oversight.
役に立ちましたか？
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What is the Department of Transportation shipping information for this product?
1 回答-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
役に立ちましたか？
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How should solutions of Product A5376, Acetylsalicylic acid, be prepared and stored?
1 回答-
Acetylsalicylic acid is slightly soluble in water, with a limit of solubility reported as approximately 3 mg/ml at 25 Deg C. It is also soluble in ethanol at 50 mg/ml and will dissolve in solutions of alkali hydroxides and carbonates with decomposition. Aqueous solutions of acetylsalicylic acid are most stable at pH 2 - 3, but to assure full activity, fresh solutions are recommended.
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