539690

Protein Synthesis Initiation Inhibitor, NSC 119889

The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5′-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: Protein Synthesis Initiation Inhibitor, NSC 119889, 3,4,5,6-Tetrabromofluorescein
• 実験式（ヒル表記法）: C₂₀H₈Br₄O₅
• 分子量: 647.89
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: light brown
• 溶解性: DMSO: 200 mg/mL; methanol: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5′-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
human arginine methyl transferase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1.41 µM against human arginine methyl transferase

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable