Pre-mRNA Splicing Inhibitor, Isoginkgetin, The Pre-mRNA Splicing Inhibitor, Isoginkgetin, also referenced under CAS 548-19-6, blocks the spliceosome-meidated splicing process.
A cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 µM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
A naturally isolated Ginkgo biloba biflavanoid that acts as a cell-permeable, reversible inhibitor against spliceosome-mediated pre-mRNA splicing (IC50 and ICmax = 30 and 50 µM, respectively, in splicing assays using HeLa nuclear extract) by preventing the prespliceosome A complex from recruiting the U4/U5/U6 tri-snRNP (stable nuclear RNA and its associated proteins) to form B complex. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
その他情報
Kim, H.Y., et al. 2008. Arch. Pharm. Res.31, 265. O′Brien, K., et al. 2008. J. Biol. Chem.283, 33147. Yoon, S,O., et al. 2006. Mol. Cancer Ther.5, 2666.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
The Journal of biological chemistry, 283(48), 33147-33154 (2008-10-02)
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Archives of pharmacal research, 31(3), 265-273 (2008-04-15)
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Molecular cancer therapeutics, 5(11), 2666-2675 (2006-11-24)
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