251800

Daunorubicin, Hydrochloride

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome c oxidase.

• 別名: Daunorubicin, Hydrochloride, Daunomycin, HCl
• 実験式（ヒル表記法）: C₂₇H₂₉NO₁₀ · xHCl
• CAS番号: 23541-50-6
• 分子量: 527.52 (free base basis)
• MDL番号: MFCD04974507
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• フォーム: crystalline solid
• 有効性: ≥840 g/kg
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: red
• 溶解性: aqueous buffer: soluble; methanol: soluble; water: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
• InChI Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N

詳細

詳細

Potent cell-permeable anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis and to intercalate into DNA. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
DNA synthesis, RNA synthesis

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

再構成

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 1 month at 4°C.

その他情報

Friedenberg, W.R., et al. 1995. Am. J. Clin. Oncol. 18, 105.
Papadopoulou, L.C., and Tsiftsoglou, A.S. 1993. Cancer Res. 53, 1072.
Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol.46, 375.
Wolff, M., and Jelkmann, W. 1993. Ann. Hematol. 66, 27.
Bellec, F., et al. 1992. Flow Cytometry 13, 880.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H341,H351,H360FD
• 注意書き: P202 - P264 - P280 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3