An anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.
An antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.
生物化学的／生理学的作用
Primary Target sterol & fatty acid biosynthesis
包装
Packaged under inert gas
警告
Toxicity: Harmful (C)
その他情報
Loftus, T.M., et al. 2000. Science288, 2379. Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90. Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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