219261

Catalase, Aspergillus niger

Catalase, Aspergillus niger, CAS 9001-05-2, is a native, long-acting, extremely stable form of catalase that is active over a wide pH range (pH 1 - 12).

• 別名: Catalase, Aspergillus niger
• CAS番号: 9001-05-2
• Enzyme Commission number: 1.11.1.6 (BRENDA, IUBMB)
• MDL番号: MFCD00081483
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• 形状: lyophilized powder
• 比活性: ≥10,000 units/mg protein; ≥4000 units/mg dry wt.
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: green
• 溶解性: H₂O: 1 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C
• InChI: 1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
• InChI Key: NUVBSKCKDOMJSU-UHFFFAOYSA-N

詳細

詳細

Research area: Cell Signaling

Catalase, Aspergillus niger, is a native, long-acting, extremely stable form of catalase that is active over a wide pH range (pH 1 - 12). Composed of four protein subunits, each containing a heme group bound to its active site, it is one of the most important antioxidant enzymes present in almost all aerobic organisms.

アプリケーション

Catalase may be used in:

• Industrial applications for eliminating hydrogen peroxide, which is utilized as an oxidizing, bleaching, or sterilizing agent.
• Food industry and egg processing, often in conjunction with other enzymes.
• Food preservation methods in combination with glucose oxidase, where superoxide dismutase produces H2O2, which is subsequently eliminated by catalase.
• Preservation process, along with glucose oxidase.

生物化学的／生理学的作用

Catalase is responsible for breaking down two hydrogen peroxide molecules into one oxygen molecule and two water molecules in a two-step reaction. It plays a crucial role in regulating the cellular level and catabolism of hydrogen peroxide which in turn shields the cells from oxidative damage. Its malfunctioning and deficiency is linked to various diseases, including vitiligo, diabetes mellitus, anemia, cardiovascular diseases, bipolar disorders, Wilson disease, certain dermatological disorders, Alzheimer′s disease, hypertension, and schizophrenia. Anomalies in catalase activity are related to acatalasemia or Takahara disease, a rare genetic disorder.

警告

Toxicity: Standard Handling (A)

単位の定義

One unit is defined as the amount of enzyme that will decompose 1.0 µmol H₂O₂ per min at 30°C, pH 7.0.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Note: 1 KU = 1000 units

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H334
• 注意書き: P261 - P284 - P501
• 危険有害性の分類: Resp. Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable