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安全性情報

41996

Sigma-Aldrich

1-Hydroxy-7-azabenzotriazole solution

~0.6 M in DMF, for peptide synthesis

別名:

3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol, HOAt

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About This Item

実験式（ヒル表記法）:
C5H4N4O
CAS番号:
39968-33-7
分子量:
136.11
Beilstein:
1211115
MDL番号:
MFCD00210053
UNSPSCコード:
12352005
PubChem Substance ID:
57650093
NACRES:
NA.22

製品名

1-Hydroxy-7-azabenzotriazole solution, ~0.6 M in DMF

フォーム

liquid

品質水準

100

反応適合性

reaction type: Addition Reactions

濃度

~0.6 M in DMF

不純物

<1.0% water

屈折率

n20/D 1.441

密度

0.978 g/mL at 20 °C

アプリケーション

peptide synthesis

SMILES記法

On1nnc2cccnc12

InChI

1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H

InChI Key

FPIRBHDGWMWJEP-UHFFFAOYSA-N

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詳細

1-Hydroxy-7-azabenzotriazole solution, also known as 3H-[1,2,3]-triazolo[4,5-b]pyridin-3-ol, is a benzotriazolic additive that is commonly used as a coupling reagent for amino acids and peptides. It is also used to minimize epimerization. [1] [2]

アプリケーション

1-Hydroxy-7-azabenzotriazole solution is used as a reagent in the solid-phase synthesis of chiral peptide nucleic acids. [3]

その他情報

Coupling additive for efficient racemization-free coupling in peptide synthesis;[4][5][6] segment coupling.[7]

ピクトグラム

FlameHealth hazardExclamation mark
GHS02,GHS08,GHS07

シグナルワード

Danger

危険有害性情報

H226,H312 + H332,H319,H360D

危険有害性の分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

保管分類コード

3 - Flammable liquids

WGK

WGK 3

引火点(°F)

136.4 °F - closed cup

引火点(℃)

58 °C - closed cup

個人用保護具 (PPE)

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

PRTR

第一種指定化学物質

消防法

第4類:引火性液体
第二石油類
危険等級III
非水溶性液体

労働安全衛生法名称等を表示すべき危険物及び有害物

名称等を表示すべき危険物及び有害物

労働安全衛生法名称等を通知すべき危険物及び有害物

名称等を通知すべき危険物及び有害物

Jan Code

41996-1EA-F:
41996-100ML-F:4548173148212
41996-25ML-F:4548173148229
41996-VAR-F:
41996-BULK-F:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
BCCN0107
BCCK9699
BCCL1807
BCCJ9637
BCCH0686

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While revisiting biologically active natural peptides, the importance of the tryptophan residue became clear. In this article, the incorporation of this amino acid, brominated at different positions of the indole ring, into cyclic peptides was successfully achieved. These products demonstrated
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質問

1–2/2 質問  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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