134910

(1R,2S)-(−)-Ephedrine

98%

• 別名: (−)-Ephedrine, (1R,2S)-(−)-α-(1-Methylaminoethyl)benzyl alcohol, (1R,2S)-(−)-2-Methylamino-1-phenyl-1-propanol, L-α-(1-Methylaminoethyl)benzyl alcohol
• 化学式: C₆H₅CH[CH(NHCH₃)CH₃]OH
• CAS番号: 299-42-3
• 分子量: 165.23
• Beilstein: 2208730
• EC Number: 206-080-5
• MDL番号: MFCD00064257
• UNSPSCコード: 12352116
• PubChem Substance ID: 24848190
• NACRES: NA.22

特性

• 品質水準: 200
• アッセイ: 98%
• フォーム: solid
• 光学活性: [α]21/D −41°, c = 5 in 1 M HCl
• bp: 255 °C (lit.)
• mp: 37-39 °C (lit.)
• 密度: 1.124 g/mL at 25 °C (lit.)
• 官能基: amine; hydroxyl; phenyl
• 保管温度: 2-8°C
• SMILES記法: CN[C@@H](C)[C@H](O)c1ccccc1
• InChI: 1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
• InChI Key: KWGRBVOPPLSCSI-WPRPVWTQSA-N

詳細

詳細

(1R,2S)-(-)-Ephedrine, a chiral β-amino alcohol, is commonly used as a chiral auxiliary in asymmetric synthesis.[1] It undergoes reduction to form (+)-methamphetamine.[2]

アプリケーション

(1R,2S)-(-)-Ephedrine can be used in the preparation of optically active phosphine-phosphonite ligands[3] and chirally-substituted cyclopentadienyl (Cp) ligands.[4] It reacts with phosphorus trichloride to form (2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine.[5] It can also act as a chiral resolving agent for (±)-mandelic acid.[6]

Versatile chiral synthon,[7] employed in catalysis[8] and in the preparation of optically pure sulfoxides[9] and oxazolidines.[10]

安全性情報

• ピクトグラム: GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H314,H317
• 注意書き: P260 - P272 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1B
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• 引火点(°F): 186.8 °F - closed cup
• 引火点(℃): 86 °C - closed cup
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves