Passa al contenuto
Merck

Plasma leucine enkephalin is increased in liver disease.

Gut (1989-10-01)
J R Thornton, M S Losowsky
ABSTRACT

Plasma methionine enkephalin is increased in liver disease and may contribute to some of the clinical manifestations of hepatic failure. To determine if another 'small' opioid peptide is increased in the plasma of patients with liver disease, leucine enkephalin was measured by radioimmunoassay. Its plasma concentration was raised approximately five-fold in patients with acute liver disease (median 1490 pmol/l, range 830-2420) and three-fold in patients with cirrhosis with ascites (960 pmol/l, 470-2900), compared with disease controls (325 pmol/l, 180-740) and healthy controls (305 pmol/l, 180-560). The increase in plasma leucine enkephalin was proportional to the degree of liver damage, as judged in the patients with acute liver disease by its correlation with the prothrombin time (r = 0.691, p less than 0.01) and alanine aminotransferase (r = 0.502, p less than 0.05), and in the patients with cirrhosis by its negative correlation with the plasma albumin (r = -0.743, p less than 0.001). It is unclear whether the raised plasma leucine enkephalin in liver disease is a consequence of diminished hepatic inactivation, increased secretion from sympathetic nerves and adrenal glands, or both.

MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto

Sigma-Aldrich
Urea, powder, BioReagent, for molecular biology, suitable for cell culture
Sigma-Aldrich
1,2-propandiolo, ≥99.5% (GC), FCC, FG
Sigma-Aldrich
Acido linoleico, ≥99%
Supelco
Urea, 8 M (after reconstitution with 16 mL high purity water)
Sigma-Aldrich
Urea solution, BioUltra, ~8 M in H2O
Sigma-Aldrich
L-Aspartic acid, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
Acido linoleico, liquid, BioReagent, suitable for cell culture
Sigma-Aldrich
Urea, BioXtra, pH 7.5-9.5 (20 °C, 5 M in H2O)
Sigma-Aldrich
Creatine, anhydrous
Sigma-Aldrich
Urea, BioUltra, for molecular biology, 99% (T)
Sigma-Aldrich
Urea, ACS reagent, 99.0-100.5%
Sigma-Aldrich
L-Aspartic acid, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
Tyramine, ≥98.0%
Sigma-Aldrich
1,2-propandiolo, ACS reagent, ≥99.5%
Sigma-Aldrich
Urea, suitable for electrophoresis
Sigma-Aldrich
2,3-Butanediol, 98%
Sigma-Aldrich
L-Aspartic acid, BioXtra, ≥99% (HPLC)
Sigma-Aldrich
Propylene Glycol, meets USP testing specifications
Supelco
1,2-propandiolo, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Acido linoleico, technical, 58-74% (GC)
Sigma-Aldrich
L-Aspartic acid, BioUltra, ≥99.5% (T)
Sigma-Aldrich
Urea, meets USP testing specifications
Sigma-Aldrich
1,2-propandiolo, ReagentPlus®, 99%
Sigma-Aldrich
Urea solution, 40 % (w/v) in H2O
Sigma-Aldrich
Urea, ReagentPlus®, ≥99.5%, pellets
SAFC
L-Aspartic acid
Supelco
Acido linoleico, analytical standard
Sigma-Aldrich
Tyramine, 98%, FG
Sigma-Aldrich
1,2-propandiolo, puriss. p.a., ACS reagent, ≥99.5% (GC)
Supelco
1,2-propandiolo, analytical standard