X2254

XE-991

≥98% (HPLC), powder, KCNQ channel blocker

• Sinonimo/i: 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
• Formula empirica (notazione di Hill): C₂₆H₂₀N₂O
• Numero CAS: 122955-42-4
• Peso molecolare: 376.45
• Numero MDL: MFCD05662331
• Codice UNSPSC: 12352200
• ID PubChem: 329830775
• NACRES: NA.77

Proprietà

• Nome del prodotto: XE-991, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Colore: white to beige
• Solubilità: DMSO: >20 mg/mL
• Ideatore: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15
• InChI: 1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2; KHJFBUUFMUBONL-UHFFFAOYSA-N

Descrizione

Applicazioni

XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization.[1] It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).[2]

Azioni biochim/fisiol

XE-991 is a KCNQ channel blocker.

XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable