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T6700

Sigma-Aldrich

TRAM-34

≥98% (HPLC), solid

Sinonimo/i:

1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

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About This Item

Formula empirica (notazione di Hill):
C22H17ClN2
Numero CAS:
289905-88-0
Peso molecolare:
344.84
Numero MDL:
MFCD09842562
Codice UNSPSC:
12352200
ID PubChem:
329826852
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

off-white

Solubilità

DMSO: 2 mg/mL
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4

InChI

1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
KBFUQFVFYYBHBT-UHFFFAOYSA-N

Applicazioni

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Azioni biochim/fisiol

TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.
TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H413

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 4

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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