C2759

Carbonyl Cyanide m-Chlorophenylhydrazone

≥97% (TLC), powder, mitophagy inducer

• Sinonimo/i: m-Cl-CCP, CCCP, Mesoxalonitrile 3-chlorophenylhydrazone
• Formula empirica (notazione di Hill): C₉H₅ClN₄
• Numero CAS: 555-60-2
• Peso molecolare: 204.62
• Beilstein: 1842102
• Numero CE: 209-103-7
• Numero MDL: MFCD00001848
• Codice UNSPSC: 12352200
• ID PubChem: 24892523
• NACRES: NA.77

Proprietà

• product name: Carbonyl cyanide 3-chlorophenylhydrazone, ≥97% (TLC), powder
• Saggio: ≥97% (TLC)
• Forma fisica: powder
• Colore: yellow to orange
• Solubilità: DMSO: 100 mM
• Temperatura di conservazione: −20°C
• Stringa SMILE: Clc1cccc(N\N=C(\C#N)C#N)c1
• InChI: 1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H; UGTJLJZQQFGTJD-UHFFFAOYSA-N

Descrizione

Applicazioni

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) has been used:

• in the inhibition of efflux pump in clinical Pseudomonas aeruginosa
• to inhibit oxidative phosphorylation activity of mitochondria in human Beas-2B bronchial epithelial cells
• to prepare carbonyl cyanide m-chlorophenylhydrazone solution for oxidative and mitochondrial stress assay and mitophagy induction in Caenorhabditis elegans

Azioni biochim/fisiol

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induces mitophagy in mammalian cells. CCCP suppresses the expression of few electron transport chain (ETC) proteins. Protonophore (H⁺ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. Shown to have a number of effects on cellular calcium. Inhibits secretion of hepatic lipase and partially inhibits the pH gradient-activated Cl^- uptake and Cl^-/Cl^- exchange activities in brush-border membrane vesicles.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301 + H311 + H331,H315,H319,H335
• Consigli di prudenza: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges