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T1573

Sigma-Aldrich

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

Sinonimo/i:

TRAP-6

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About This Item

Formula empirica (notazione di Hill):
C34H56N10O9
Numero CAS:
141136-83-6
Peso molecolare:
748.87
Numero MDL:
MFCD00238172
Codice UNSPSC:
12352200
ID PubChem:
329826680
NACRES:
NA.77

Livello qualitativo

200

Saggio

>95% (HPLC)

Forma fisica

lyophilized

tecniche

cell culture | mammalian: suitable

Solubilità

0.1% TFA: soluble
water: soluble

N° accesso UniProt

P25116

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
HAGOWCONESKMDW-FRSCJGFNSA-N

Informazioni sul gene

human ... F2R(2149)

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

Descrizione generale

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Applicazioni

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Azioni biochim/fisiol

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).

Altre note

Lyophilized from 0.1% TFA in H2O

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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PloS one, 14(1), e0211130-e0211130 (2019-01-24)
Flow cytometric platelet activation has emerged as an alternative diagnostic test for inherited platelet disorders. It is, however, labor intensive and few studies have directly compared the performance of flow cytometric platelet activation (PACT) to light transmission aggregometry (LTA). The
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Platelets are important for effective hemostasis and considered to be involved in pathophysiological processes, e.g. in cardiovascular diseases. Platelets provided for research or for therapeutic use are frequently separated from citrated whole blood (WB) stored for different periods of time.
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