Soluble at 50mg/ml, it can be dissolved in water, but it is recommended to use saline, NaCl, DPBS, Hanks, or culture medium. Please note that a reference in peer- reviewed papers at sial.com isolated glomerular endothelial cells at 0.1% in DMEM. This paper may also be of reference "Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells (https://www.sciencedirect.com/science/article/pii/S0006291X02006939?via%3Dihub)
P5515
Prostaglandin E1
≥98% (HPLC), powder, vasodilator
Sinonimo/i:
(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1
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1 MG
207,00 €
5 MG
437,00 €
10 MG
561,00 €
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Cambia visualizzazione
1 MG
207,00 €
5 MG
437,00 €
10 MG
561,00 €
About This Item
Formula empirica (notazione di Hill):
C20H34O5
Numero CAS:
Peso molecolare:
354.48
Beilstein:
5294062
Numero CE:
Numero MDL:
Codice UNSPSC:
12352211
eCl@ss:
42020658
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Prostaglandin E1, ≥98% (HPLC), synthetic
Origine biologica
synthetic
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
(powder to crystals)
Solubilità
ethanol: 5 mg/mL
Temperatura di conservazione
−20°C
Stringa SMILE
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
InChI
1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
GMVPRGQOIOIIMI-DWKJAMRDSA-N
Informazioni sul gene
human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)
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Applicazioni
Azioni biochim/fisiol
Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase.[4] It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease.[5] It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site.[6] It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO).[7] PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML). [8]
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 3 Oral
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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I clienti hanno visto anche
Mélanie Abonnenc et al.
Blood transfusion = Trasfusione del sangue, 13(2), 255-264 (2014-11-05)
The Intercept Blood SystemTM (Cerus) is used to inactivate pathogens in platelet concentrates (PC). The aim of this study was to elucidate the extent to which the Intercept treatment modifies the functional properties of platelets. A two-arm study was conducted
Yosuke Okamura et al.
Biophysical journal, 100(8), 1855-1863 (2011-04-21)
Eukaryotic cells respond to signaling molecules with picomolar to nanomolar sensitivities. However, molar concentrations give no suggestion of the sufficient number of molecules per cell and are confusing when referring to physiological situations in which signaling molecules act in an
Synthesis of prostaglandin E 1 phosphate derivatives and their encapsulation in biodegradable nanoparticles
Takeda M, et al.
Pharmaceutical Research, 26(7), 1792-1800 (2009)
Intravenous infusion of prostaglandin E1 therapy in extremity ischemia
Ramakrishna P
Indian Journal of Vascular and Endovascular Surgery, 4(2), 38-38 (2017)
Prostaglandins and thromboxanes.
B Samuelsson et al.
Annual review of biochemistry, 47, 997-1029 (1978-01-01)
Articoli
Discover Bioactive Small Molecules for Lipid Signaling Research
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Is stability in solution information available for the product P5515?
Is stability in solution information available for the product P5515?
1 risposta-
Utile?
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What are the recommended storage temperature conditions for Prostaglandin E1 (P5515) when dissolved in acetone?
1 risposta-
The solubility test is designed to ensure the product is free of foreign bodies or other unsoluble substances. Acetone was choosen for the solubility test because appears to have higher solubility in acetone than it does in ethanol. The Quality department will dissolve the product in acetone and discard the solution once the solubility test is complete. So there is no data for what is the preferred storage temperature and length of storage if using acetone as the solvent.
Utile?
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