SRP3331
G-CSF from mouse
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Sinonimo/i:
CSF-3, MGI-1G, pluripoietin
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10 μG
382,00 €
382,00 €
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Cambia visualizzazione
10 μG
382,00 €
About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
382,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
mouse
Ricombinante
expressed in E. coli
Saggio
≥98% (HPLC)
≥98% (SDS-PAGE)
Stato
lyophilized
Potenza
≤0.05 ng/mL
PM
19.0 kDa
Confezionamento
pkg of 10 μg
Impurezze
endotoxin, tested
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... CSF3(12985)
Descrizione generale
Colony stimulating factor 3 (CSF-3) or granulocyte colony stimulating factor (G-CSF) is a hematopoietic growth factor. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma.[1] Human and murine G-CSF is cross-species reactive. Recombinant murine G-CSF is a 19.0kDa protein consisting of 179 amino acid residues.
Azioni biochim/fisiol
Colony stimulating factor 3 (CSF-3) or granulocyte colony stimulating factor (G-CSF) stimulates the development of committed progenitor cells to neutrophils[2] and enhances the functional activities of the mature end-cell. It also has a role in macrophage generation and may be involved in immune modulation.[2] G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation.
Stato fisico
Lyophilized from 10 mM Sodium Citrate, pH 4.0.
Ricostituzione
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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The importance of the granulocyte-colony stimulating factor in oncology.
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H S Lu et al.
Archives of biochemistry and biophysics, 268(1), 81-92 (1989-01-01)
Molecular characteristics and secondary structures of recombinant methionyl human granulocyte colony stimulating factor produced by genetically engineered Escherichia coli are described. Limited radiolabeling of the protein with tritiated iodoacetate and determination of the labeled residue revealed that this recombinant protein
Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.
Meshkibaf S
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Neutrophils are key innate immune effector cells that are essential to fighting bacterial and fungal pathogens. Here we report that mice carrying a hematopoietic lineage-specific deletion of Jagn1 (encoding Jagunal homolog 1) cannot mount an efficient neutrophil-dependent immune response to
Yaron Vagima et al.
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Pneumonic plague is a fatal disease caused by Yersinia pestis that is associated with a delayed immune response in the lungs. Because neutrophils are the first immune cells recruited to sites of infection, we investigated the mechanisms responsible for their
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