SML3460

CB-103

≥97% (HPLC)

• Sinonimo/i: 6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine, CB 103, CB103
• Formula empirica (notazione di Hill): C₁₅H₁₈N₂O
• Numero CAS: 218457-67-1
• Peso molecolare: 242.32
• Numero MDL: MFCD00052647
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Stato: powder
• Colore: , White to very dark gray
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: -10 to -25°C
• Stringa SMILE: Nc1cnc(cc1)Oc2ccc(cc2)C(C)(C)C
• InChI: 1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3; WHIWGRCYMQLLAO-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

CB-103 is an orally active Notch transcription activation inhibitor that targets RBPJ-Notch intracellular domain (NICD) transcription complex assembly. CB-103 exhibits antiproliferation efficacy against Notch-driven cancer growth in cultures (IC50 from 50 nM to 3 μM; patient-derived T-ALL cells positive for N1-ICD) and in tumor models in vivo (10-25 mg/kg qd or bid p.o. to mice with human T-ALL xenografts).

Orally active Notch transcription activation inhibitor with anti-cancer efficacy in cultures and in vivo.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable