S3944

SEW2871

≥98% (HPLC), solid

• Sinonimo/i: 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole
• Formula empirica (notazione di Hill): C₂₀H₁₀F₆N₂OS
• Numero CAS: 256414-75-2
• Peso molecolare: 440.36
• Numero MDL: MFCD00096600
• Codice UNSPSC: 12352211
• ID PubChem: 24724607
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: solid
• Condizioni di stoccaggio: protect from light
• Colore: white
• Punto di fusione: 94.5-95.3 °C
• Solubilità: DMSO: ≥10 mg/mL; H₂O: insoluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
• InChI: 1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H; OYMNPJXKQVTQTR-UHFFFAOYSA-N
• Informazioni sul gene: human ... S1PR1(1901) , S1PR2(9294) , S1PR3(1903) , S1PR4(8698) , S1PR5(53637)

Descrizione

Applicazioni

SEW2871 has been used as a sphingosine-1 phosphate (S1P) receptor agonist to determine the effects of reconstituting plasma apolipoprotein M (ApoM) /S1P on vascular permeability in mice.[1]

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.[2]

Azioni biochim/fisiol

Novel, selective human sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist.

SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation.[3] SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration.[4] By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.[5]

Caratteristiche e vantaggi

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Confezionamento

Light sensitive.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges