SML0700, FTY720 is soluble in water but not very soluble in PBS. The solubility in PBS is likely to be well below 100 µM, perhaps as low as 1-10 µg/mL. Other solvents for this item include DMF, DMSO, Ethanol, and Ethanol:PBS (pH 7.2) (1:1).
SML0700
FTY720
≥98% (HPLC), powder, sphingosine 1-phosphate receptor modulator
Sinonimo/i:
2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride, Fingolimod hydrochloride
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Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
5 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 85,10 € |
25 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 341,00 € |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C19H33NO2 · HCl
Numero CAS:
Peso molecolare:
343.93
UNSPSC Code:
12352211
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
85,10 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
FTY720, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
water: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
Cl.NC(CO)(CO)CCc1ccc(cc1)CCCCCCCC
InChI
1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChI key
SWZTYAVBMYWFGS-UHFFFAOYSA-N
Application
FTY720 has been used as an immunomodulator and is used to investigate its effect on in vitro gastrulation model of P19C5 stem cells. It is also used to determine its efficacy in prolonging the survival corneal transplantation. FTY720 has been used to study its effect on the proliferation and differentiation of cultured embryonic hippocampal neural stem cells (NSCs) using the 5-bromo-2-deoxyuridine incorporation assay, the neurosphere formation assay and western blot analysis.
Biochem/physiol Actions
FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.
FTY720, an immunomodulating drug, acts as a sphingosine 1-phosphate (S1P) receptor modulator.
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Questo articolo | |||
|---|---|---|---|
| description ≥98% (HPLC) | description United States Pharmacopeia (USP) Reference Standard | description - | description European Pharmacopoeia (EP) Reference Standard |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level - | Quality Level 300 | Quality Level - |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-30°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition protect from light | storage condition - | storage condition protect from light |
| solubility water: 10 mg/mL, clear | solubility ethyl acetate: soluble, water: soluble, DMSO: soluble | solubility - | solubility water: 100-1000 g/L |
Parola di avvertenza
Warning
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
STOT RE 2
Organi bersaglio
Immune system
Classe di stoccaggio
11 - Combustible Solids
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
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What is the solubility of SML0700, FTY720 in PBS?
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