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S0278

Sigma-Aldrich

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

Sinonimo/i:

N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C12H20N2O3S · HCl
Numero CAS:
959-24-0
Peso molecolare:
308.82
Numero CE:
213-496-0
Numero MDL:
MFCD00242937
Codice UNSPSC:
12352200
ID PubChem:
24278689
NACRES:
NA.77

product name

(±)-Sotalol hydrochloride, ≥98% (TLC), powder

Livello qualitativo

200

Saggio

≥98% (TLC)

Forma fisica

powder

Colore

white to off-white

Solubilità

H2O: 20 mg/mL

Ideatore

Bayer

Stringa SMILE

Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

InChI

1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
VIDRYROWYFWGSY-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)

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Applicazioni

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.

Azioni biochim/fisiol

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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A Antony Muthu Prabhu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 95-107 (2012-06-05)
The inclusion complexation behavior of salbutamol, sotalol and atenolol drugs with β-cyclodextrin (β-CD) were investigated by UV-visible, fluorometry, time resolved fluorescence, FT-IR, (1)H NMR, SEM and PM3 methods. The above drugs gave a single emission maximum in water where as
Mathias Baumert et al.
PloS one, 7(7), e41920-e41920 (2012-08-04)
Increased beat-to-beat variability in the QT interval (QTV) of ECG has been associated with increased risk for sudden cardiac death, but its measurement is technically challenging and currently not standardized. The aim of this study was to investigate the performance
Wei Liu et al.
Pharmaceutical research, 29(7), 1768-1774 (2012-02-22)
To clarify sotalol's classification in the BCS versus BDDCS systems through cellular, rat everted sac and PAMPA permeability studies. Studies were carried out in Madin Darby canine kidney (MDCK) and MDR1-transfected MDCK (MDCK-MDR1) cell lines, rat everted gut sacs and
Amee Shah et al.
The American journal of cardiology, 109(11), 1614-1618 (2012-03-27)
Fetal supraventricular tachycardia (SVT) and atrial flutter (AF) can be associated with significant morbidity and mortality. Digoxin is often used as first-line therapy but can be ineffective and is poorly transferred to the fetus in the presence of fetal hydrops.
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Reyes-Corral M, et al.
Journal of Pharmacology and Experimental Therapeutics, 369(1), 152-162 (2019)
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