The product is soluble in alcohol, ether, benzene, chloroform and oils, according to the chemicals encyclopedia published by the Royal Society of Chemistry , 14th ed. online (2006). Lidocaine hydrochloride monohydrate (Product No. L5647) is soluble in water. Since the lidocaine hydrochloride is so much more soluble than lidocaine free base, lowering the pH to that of the hydrochloride (pH 4.0-5.5) or to that of injectable forms (pH 5.0-7.0) should greatly enhance the solubility of L7757.
L7757
Lidocaine
≥98% (GC), powder, neuroprotective agent
Sinonimo/i:
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine
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25 G
72,40 €
100 G
157,00 €
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Cambia visualizzazione
25 G
72,40 €
100 G
157,00 €
About This Item
Formula empirica (notazione di Hill):
C14H22N2O
Numero CAS:
Peso molecolare:
234.34
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
Lidocaine, powder
Stato
powder
Livello qualitativo
Stringa SMILE
CCN(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
NNJVILVZKWQKPM-UHFFFAOYSA-N
Informazioni sul gene
human ... CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
rat ... Scnn1a(25122)
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Descrizione generale
Azioni biochim/fisiol
Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na+) channels.[2][4] It prevents the influx of sodium ions leading to depolarization of sodium channels[3] and metabolically inactivated in liver.[4] Lidocaine has positive effect on cerebral ischemia.[2] It is also used in the treatment of ventricular tachycardia.[4] Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.[7]
Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.
Na+ channel blocker; class IB antiarrhythmic.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 4 Oral
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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I clienti hanno visto anche
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Mitochondrial injury and caspase activation by the local anesthetic lidocaine
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Anesthesiology, 101(5), 1184-1194 (2004)
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2008)
Cytotoxicity of lidocaine to human corneal endothelial cells in vitro
Yu HZ, et al.
Basic and Clinical Pharmacology and Toxicology, 114(4), 352-359 (2014)
Eslam Nouri-Nigjeh et al.
Analytical chemistry, 82(18), 7625-7633 (2010-08-26)
The study of oxidative drug metabolism by Cytochrome P450s (P450) is important in the earlier stages of drug development. For this purpose, automated analytical techniques are needed for fast and accurate estimation of oxidative drug metabolism. Previous studies have shown
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How do I dissolve lidocaine free base (Product No. L7757)?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Is Product L7757, Lidocaine free base, suitable for use as a reference standard?
1 risposta-
No. We would recommend Product No. L1026 (Lidocaine, Sigma References Standard). The current lot is current with USP 31, 2nd Supplement, and is traceable to USP Reference Standard lot MOF220.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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