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L9133

Sigma-Aldrich

Leucine Enkephalin acetate salt hydrate

≥95% (HPLC)

Sinonimo/i:

Leucine Enkephalin

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97,20 €
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10 MG
97,20 €
25 MG
132,00 €

About This Item

Formula empirica (notazione di Hill):
C28H37N5O7 · xC2H4O2 · yH2O
Peso molecolare:
555.62 (anhydrous free base basis)
Numero MDL:
MFCD11045938
Codice UNSPSC:
12352209
eCl@ss:
32160409
ID PubChem:
329817669
NACRES:
NA.32

97,20 €

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Livello qualitativo

200

Saggio

≥95% (HPLC)

Temperatura di conservazione

−20°C

Stringa SMILE

O.CC(O)=O.CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O

InChI

1S/C28H37N5O7.C2H4O2.H2O/c1-17(2)12-23(28(39)40)33-27(38)22(14-18-6-4-3-5-7-18)32-25(36)16-30-24(35)15-31-26(37)21(29)13-19-8-10-20(34)11-9-19;1-2(3)4;/h3-11,17,21-23,34H,12-16,29H2,1-2H3,(H,30,35)(H,31,37)(H,32,36)(H,33,38)(H,39,40);1H3,(H,3,4);1H2/t21-,22-,23-;;/m0../s1
QKDIOZBQOQJXFR-XQCXOTTHSA-N

Informazioni sul gene

human ... OPRD1(4985) , OPRM1(4988)
mouse ... OPRD1(18386) , OPRM1(18390)
rat ... OPRD1(24613) , OPRM1(25601)

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu

Descrizione generale

Leucine Enkephalin is a pentapeptide and is a normal component of central and peripheral tissues.[1] Leucine Enkephalin has amino acid sequence Tyr-Gly-Gly-Phe-Leu and is distributed in the brains of many animals, including humans.[2] It is an endogenous opioid neurotransmitter/neuromodulator localized in brain parallels and in δ receptors.

Applicazioni

Leucine Enkephalin acetate salt hydrate has been used in the calibration of the Q-Tof Micro hybrid, triple quadrupole-orthogonal acceleration time of flight (TOF) instrument in single-stage TOF mode.[3] It has also been used to perform the calibration of mass spectrometry.[4] It has also been used in liquid chromatography-mass spectrometry (LCMS)/MS for calibration of the system and for relative correction of the spectra.[5][4]

Azioni biochim/fisiol

Leucine Enkephalin (LEU-ENK) functions as agonists at both μ- and δ-opioid receptor sites.[1][2] It might also play a role as neurotransmitter agent at morphine-sensitive synapses.[1] Leucine Enkephalin is also associated with pain regulation.[6] LEU-ENK expressed in camel lacrimal nerve regulates lacrimal fluid and protein secretion.[7] LEU-ENK is degraded during metabolism by several enzymes, including aminopeptidase-N (APN), neutral endopeptidase (NEP), dipeptidyl peptidase- 3 (DPP3), carboxy peptidase-A6 (CPA-6) and angiotensin converting enzyme (ACE), which are sometimes referred to as enkephalinases.[2]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000399198
0000399198
0000420149
0000420149
0000388527

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Pattern of distribution of neuropeptides in the camel lacrimal gland.
Adeghate E
Neuropeptides, 30(6), 566-571 (1996)
An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application in farmers and consumers.
Thiphom S
Analytical Methods : Advancing Methods and Applications, 4(11), 3772-3778 (2012)
OPIORPHIN AS ENDOGENOUS PEPTIDE OF HUMAN SALIVA ACTS
AS INHIBITOR OF PROTEASE ENZYMES OF ENKEPHALINS
Sarker k and Jyoti Sen D
World Journal of Pharmaceutical Research, 6, 1727-1733 (2017)
F Bolacchi et al.
Neurochemical research, 21(8), 875-884 (1996-08-01)
The hydrolysis of leucine enkephalin by the proteolytic enzymes present in human and rabbit plasma has been studied by kinetic and chromatographic techniques. Data obtained indicate the existence of noticeable intraspecific differences in the kinetics of leu-enkephalin degradation, and of
J Hughes et al.
Nature, 258(5536), 577-580 (1975-12-18)
Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by
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