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K1751

Sigma-Aldrich

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

Sinonimo/i:

2-(3-Benzoylphenyl)propionic acid

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About This Item

Formula empirica (notazione di Hill):
C16H14O3
Numero CAS:
22071-15-4
Peso molecolare:
254.28
Numero CE:
244-759-8
Numero MDL:
MFCD00055790
Codice UNSPSC:
12352200
ID PubChem:
57654315
NACRES:
NA.77

product name

Ketoprofen, ≥98% (TLC)

Origine biologica

synthetic

Saggio

≥98% (TLC)

Forma fisica

powder

Solubilità

ethanol: 50 mg/mL, clear, colorless to yellow

Ideatore

Bayer

Stringa SMILE

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
DKYWVDODHFEZIM-UHFFFAOYSA-N

Informazioni sul gene

human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

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Categorie correlate

Descrizione generale

Ketoprofen belongs to the class of 2-arylpropionic acid.

Applicazioni

Ketoprofen has been used:
  • as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
  • as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
  • in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Azioni biochim/fisiol

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.
Non-steroidal anti-inflammatory compound that is selective for COX-1.

Caratteristiche e vantaggi

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Skull and crossbonesEnvironment
GHS06,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H301,H315,H319,H400

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

F8514

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Ketoprofen-d3 VETRANAL®, analytical standard

Supelco

32673

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Diclofenac

Sigma-Aldrich

D6899

Diclofenac

vibrant-m

K2000010

Ketoprofen impurity A

Suprofen ≥98% (HPLC)

Sigma-Aldrich

SML1495

Suprofen

Fenoprofen calcium salt hydrate analytical standard, for drug analysis

Supelco

F1517

Fenoprofen calcium salt hydrate

Alosetron hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0346

Alosetron hydrochloride

Naproxen meets USP testing specifications

Sigma-Aldrich

N8280

Naproxen

Naproxen sodium 98.0-102.0%

Sigma-Aldrich

M1275

Naproxen sodium

Ekaterina Blinova et al.
Biomolecules, 11(6) (2021-07-03)
The main goal of our study was to explore the wound-healing property of a novel cerium-containing N-acethyl-6-aminohexanoate acid compound and determine key molecular targets of the compound mode of action in diabetic animals. Cerium N-acetyl-6-aminohexanoate (laboratory name LHT-8-17) as a
Polyamidoamine dendrimers used as solubility enhancers of ketoprofen
Yiyun C, et al.
European Journal of Medicinal Chemistry, 40(12), 1390-1393 (2005)
Ekaterina Blinova et al.
International journal of molecular sciences, 22(18) (2021-09-29)
The possible involvement of p53 signaling, FGFR3 expression, and FGFR3 mutation rates in the prediction of the NMIBC anti-PD-L1 treatment response needs to be clarified. The main aim of our study was to explore predictive value of p53 expression, FGFR3
In vitro chiral conversion, phase separation, and wave propagation in aged profen solutions
Sajewicz M, et al.
Journal of Liquid Chromatography and Related Technologies, 32(9), 1359-1372 (2009)
L Saso et al.
Archives of pharmacal research, 24(2), 150-158 (2001-05-08)
The activity of nonsteroidal antiinflammatory drugs (NSAIDs) in rheumatoid arthritis is not only due to the inhibition of the production of prostaglandins, which can even have beneficial immunosuppressive effects in chronic inflammatory processes. Since we speculated that these drugs could
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