I7378

Indomethacin

98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor

• Sinonimo/i: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
• Formula empirica (notazione di Hill): C₁₉H₁₆ClNO₄
• Numero CAS: 53-86-1
• Peso molecolare: 357.79
• Beilstein: 497341
• Numero CE: 200-186-5
• Numero MDL: MFCD00057095
• Codice UNSPSC: 12161501
• ID PubChem: 24278173
• NACRES: NA.77

Proprietà

• product name: Indomethacin, 98.5-100.5% (in accordance with EP)
• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: 98.5-100.5% (in accordance with EP)
• Forma fisica: powder or crystals
• Perdita: ≤0.5% loss on drying
• Punto di fusione: 158-162 °C
• Modalità d’azione: enzyme | inhibits
• Stringa SMILE: COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
• InChI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23); CGIGDMFJXJATDK-UHFFFAOYSA-N
• Informazioni sul gene: human ... ALB(213) , ALOX5(240) , ELA2(1991) , GPR44(11251) , IL1A(3552) , PLA2G1B(5319) , PTGDR(5729) , PTGS1(5742) , PTGS2(5743) ; mouse ... Alox5(11689) , Ptgdr(19214) , Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219) , Ptgs1(19224) ; rat ... Alox5(25290) , Ptgs1(24693) , Ptgs2(29527)

Descrizione

Descrizione generale

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.

Applicazioni

Indomethacin has been used:

• as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
• as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
• in the inhibition of prostaglandin E2 (PGE2) in T cells

Azioni biochim/fisiol

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 1 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges