M1275

Naproxen sodium

98.0-102.0%

• Sinonimo/i: (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt
• Formula empirica (notazione di Hill): C₁₄H₁₃NaO₃
• Numero CAS: 26159-34-2
• Peso molecolare: 252.24
• Numero CE: 247-486-2
• Numero MDL: MFCD00058507
• Codice UNSPSC: 12352200
• ID PubChem: 57654352
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic (organic)
• Saggio: 98.0-102.0%
• Stato: powder
• Solubilità: water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Ideatore: Bayer
• Stringa SMILE: [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
• InChI: 1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1; CDBRNDSHEYLDJV-FVGYRXGTSA-M
• Informazioni sul gene: human ... PTGS1(5742) , PTGS2(5743)

Descrizione

Descrizione generale

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).[1]

Applicazioni

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin.[1] It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.[2]

Azioni biochim/fisiol

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.[1]

Caratteristiche e vantaggi

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H360
• Consigli di prudenza: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classi di pericolo: Acute Tox. 4 Oral - Repr. 1A
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves