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G9003

Sigma-Aldrich

D-Glutamine

≥98% (HPLC)

Sinonimo/i:

D-2-Aminoglutaramic acid, D-Glutamic acid 5-amide

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About This Item

Formula empirica (notazione di Hill):
C5H10N2O3
Numero CAS:
Peso molecolare:
146.14
Beilstein:
1723796
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.32

product name

D-Glutamine, ≥98% (HPLC)

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white

applicazioni

cell analysis

Stringa SMILE

N[C@H](CCC(N)=O)C(O)=O

InChI

1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m1/s1
ZDXPYRJPNDTMRX-GSVOUGTGSA-N

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Descrizione generale

Glutamine is a non-essential and the most abundant free amino acid present in the human body. It is an important component of proteins and is one of the 20 proteinogenic amino acids. It forms 5-6% of bound amino acids.

Applicazioni

D-Glutamine has been used to study its role in conferring protection against acetaldehyde-induced disruption of barrier function in Caco-2 cell monolayer.

Azioni biochim/fisiol

Glutamine forms the central metabolite in amino acid transamination via a-ketoglutarate and glutamic acid. This amino acid is metabolized by different enzymes, such as glutaminase, present in liver, and glutamine synthetase, present in skeletal muscle. It is produced in the cytoplasm from other amino acids, predominantly from branched-chain amino acids and glutamate. It plays an essential role in ammonia metabolism and detoxification. Its skeletal muscle levels are significantly reduced post trauma, operation and inflammatory states. It servers as a prognostic marker in fatal sepsis during which its skeletal muscle levels are decreased by 90%.

Altre note

Unnatural isomer of glutamine

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


Certificati d'analisi (COA)

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Role of L-glutamine in the protection of intestinal epithelium from acetaldehyde-induced disruption of barrier function was evaluated in Caco-2 cell monolayer. L-Glutamine reduced the acetaldehyde-induced decrease in transepithelilal electrical resistance and increase in permeability to inulin and lipopolysaccharide in a

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