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A6185

Sigma-Aldrich

Calpain Inhibitor I

≥97% (TLC), powder

Sinonimo/i:

ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Norleu-al

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5 MG
127,00 €
25 MG
511,00 €

127,00 €

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Cambia visualizzazione
5 MG
127,00 €
25 MG
511,00 €

About This Item

Formula empirica (notazione di Hill):
C20H37N3O4
Numero CAS:
110044-82-1
Peso molecolare:
383.53
Beilstein:
7656053
Numero MDL:
MFCD00065505
Codice UNSPSC:
12352200
ID PubChem:
24891066
NACRES:
NA.77

127,00 €

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Origine biologica

synthetic (organic)

Livello qualitativo

200

Saggio

≥97% (TLC)

Stato

powder

Colore

white

Solubilità

DMSO: soluble
ethanol: soluble

Temperatura di conservazione

−20°C

Stringa SMILE

[H]C(=O)[C@H](CCCC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

InChI

1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
FMYKJLXRRQTBOR-BZSNNMDCSA-N

Informazioni sul gene

human ... CAPN1(823) , CTSB(1508) , PSMA1(5682)

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Applicazioni

Calpain Inhibitor I have been used:
  • as a component of protease inhibitor cocktail for gel shift analysis[1]
  • for treating HeLa cell cultures[2]
  • for inhibition of 26 S proteasome in 26 S proteasome inhibition assays[3]

Azioni biochim/fisiol

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis.[4] It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..[5]
Can initiate apoptosis in HL-60 cells[6] but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes.[7] Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.[8] Blocks induction of nitric oxide synthase by LPS in macrophages.[9]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCQ7536
MKCM9527
MKCH5697
MKBW6115V
SLBM0472V

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PD 150606 ≥97% (HPLC)

Sigma-Aldrich

D5946

PD 150606

Calpastatin Peptide Ac 184-210 ≥95% (HPLC)

Sigma-Aldrich

SCP0063

Calpastatin Peptide Ac 184-210

ALLM Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM).

Sigma-Aldrich

208721

ALLM

Calpain Inhibitor VI The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

208745

Calpain Inhibitor VI

S W Sherwood et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(8), 3353-3357 (1993-04-15)
The cytotoxic neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal (ALLN) inhibits cell-cycle progression in CHO cells, affecting the G1/S and metaphase-anaphase transition points, as well as S phase. Mitotic arrest induced by ALLN is associated with the inhibition of cyclin B degradation.
Cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis
Nakagawa T and Yuan J
The Journal of Cell Biology, 150(4), 887-894 (2000)
Q Lu et al.
Archives of biochemistry and biophysics, 334(1), 175-181 (1996-10-01)
Recent investigations indicate that proteolysis is an important event in generation of the apoptosis phenotype. Although various proteases have been suggested to be candidates for this proteolysis, the results from different laboratories are inconsistent. In the present studies, HL-60 cells
M K Squìer et al.
Journal of cellular physiology, 159(2), 229-237 (1994-05-01)
Programmed cell death is an active process wherein the cell initiates a sequence of events culminating in the fragmentation of its DNA, nuclear collapse, and disintegration of the cell into small, membrane-bound apoptotic bodies. Examination of the death program in
Cleavage of the calpain inhibitor, calpastatin, during apoptosis
Porn-Ares M I, et al.
Cell Death and Differentiation, 5(12), 1028-1028 (1998)
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